Is the Phenomenon of Mefenoxam-Acquired Resistance in Phytophthora infestans Universal?
Identifieur interne : 000138 ( Main/Exploration ); précédent : 000137; suivant : 000139Is the Phenomenon of Mefenoxam-Acquired Resistance in Phytophthora infestans Universal?
Auteurs : Juliana González-Tob N [Colombie] ; Richard Childers [États-Unis] ; Carolina Olave [Colombie] ; Melissa Regnier [Colombie] ; Alejandra Rodríguez-Jaramillo [Colombie] ; William Fry [États-Unis] ; Silvia Restrepo [Colombie] ; Giovanna Danies [Colombie]Source :
- Plant disease [ 0191-2917 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Alanine.
- effets des médicaments et des substances chimiques : Phytophthora infestans.
- microbiologie : Solanum tuberosum.
- pharmacologie : Alanine, Fongicides industriels.
- Résistance des champignons aux médicaments.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Alanine.
- chemical , pharmacology : Alanine, Fungicides, Industrial.
- drug effects : Phytophthora infestans.
- microbiology : Solanum tuberosum.
- Drug Resistance, Fungal.
Abstract
Phytophthora infestans is the causal agent of late blight disease of potatoes and tomatoes. This disease causes devastating economic losses each year, and control is mainly achieved by the use of fungicides. Unfortunately, populations of P. infestans resistant to fungicides have been documented. Furthermore, studies have reported that sensitive isolates to the phenylamide fungicide, mefenoxam, become less sensitive in vitro after a single passage through sublethal concentrations of fungicide-amended medium. The first objective of this study was to investigate if isolates of P. infestans are capable of acquiring resistance to two additional systemic fungicides, fluopicolide (benzamide) and cymoxanil (cyanoacetamide-oxime). In contrast to the situation with mefenoxam, exposure of isolates to sublethal concentrations of fluopicolide and cymoxanil did not induce reduced sensitivity to these two fungicides. The second objective was to assess if reduced sensitivity to mefenoxam could occur in naturally sensitive isolates of other Phytophthora species and of Phytopythium sp., another oomycete plant pathogen. All Phytophthora spp. assessed (P. infestans, P. betacei, and P. pseudocryptogea) as well as Phytopythium sp. acquired resistance to mefenoxam after previous exposure through medium containing 1 µg ml-1 of mefenoxam. Interestingly, isolate 66 of Phytopythium sp. and the isolate of P. pseudocryptogea tested do not seem to be acquiring resistance to mefenoxam after exposure to medium containing 5 µg ml-1 of this fungicide. The tested isolates of P. palmivora and P. cinnamomi were extremely sensitive to mefenoxam, and thus it was not possible to perform a second transfer to access acquisition of resistance to this fungicide.
DOI: 10.1094/PDIS-10-18-1906-RE
PubMed: 31765279
Affiliations:
- Colombie, États-Unis
- Massachusetts, État de New York
- Cambridge (Massachusetts), Ithaca (New York)
- Université Cornell, Université Harvard
Links toward previous steps (curation, corpus...)
Le document en format XML
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wicri:stream="Main" wicri:step="Curation">000340</idno><idno type="wicri:Area/Main/Exploration">000340</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is the Phenomenon of Mefenoxam-Acquired Resistance in <i>Phytophthora infestans</i> Universal?</title><author><name sortKey="Gonzalez Tob N, Juliana" sort="Gonzalez Tob N, Juliana" uniqKey="Gonzalez Tob N J" first="Juliana" last="González-Tob N">Juliana González-Tob N</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Department of Biological Sciences, Universidad de los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Childers, Richard" sort="Childers, Richard" uniqKey="Childers R" first="Richard" last="Childers">Richard Childers</name><affiliation wicri:level="4"><nlm:affiliation>Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Cambridge (Massachusetts)</settlement></placeName><orgName type="university">Université Harvard</orgName></affiliation></author><author><name sortKey="Olave, Carolina" sort="Olave, Carolina" uniqKey="Olave C" first="Carolina" last="Olave">Carolina Olave</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Department of Biological Sciences, Universidad de los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Regnier, Melissa" sort="Regnier, Melissa" uniqKey="Regnier M" first="Melissa" last="Regnier">Melissa Regnier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Department of Biological Sciences, Universidad de los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Jaramillo, Alejandra" sort="Rodriguez Jaramillo, Alejandra" uniqKey="Rodriguez Jaramillo A" first="Alejandra" last="Rodríguez-Jaramillo">Alejandra Rodríguez-Jaramillo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Department of Biological Sciences, Universidad de los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Fry, William" sort="Fry, William" uniqKey="Fry W" first="William" last="Fry">William Fry</name><affiliation wicri:level="4"><nlm:affiliation>School of Integrative Plant Science, Plant Pathology and Plant-Microbe Biology Section, Cornell University, Ithaca, NY, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Integrative Plant Science, Plant Pathology and Plant-Microbe Biology Section, Cornell University, Ithaca, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Ithaca (New York)</settlement></placeName><orgName type="university">Université Cornell</orgName></affiliation></author><author><name sortKey="Restrepo, Silvia" sort="Restrepo, Silvia" uniqKey="Restrepo S" first="Silvia" last="Restrepo">Silvia Restrepo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Department of Biological Sciences, Universidad de los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Danies, Giovanna" sort="Danies, Giovanna" uniqKey="Danies G" first="Giovanna" last="Danies">Giovanna Danies</name><affiliation wicri:level="1"><nlm:affiliation>Department of Design, Universidad de los Andes, Bogotá, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Department of Design, Universidad de los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author></analytic><series><title level="j">Plant disease</title><idno type="ISSN">0191-2917</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alanine (analogs & derivatives)</term><term>Alanine (pharmacology)</term><term>Drug Resistance, Fungal (MeSH)</term><term>Fungicides, Industrial (pharmacology)</term><term>Phytophthora infestans (drug effects)</term><term>Solanum tuberosum (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alanine (analogues et dérivés)</term><term>Alanine (pharmacologie)</term><term>Fongicides industriels (pharmacologie)</term><term>Phytophthora infestans (effets des médicaments et des substances chimiques)</term><term>Résistance des champignons aux médicaments (MeSH)</term><term>Solanum tuberosum (microbiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Alanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Alanine</term><term>Fungicides, Industrial</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Alanine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Solanum tuberosum</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Solanum tuberosum</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Alanine</term><term>Fongicides industriels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Resistance, Fungal</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Résistance des champignons aux médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><i>Phytophthora infestans</i> is the causal agent of late blight disease of potatoes and tomatoes. This disease causes devastating economic losses each year, and control is mainly achieved by the use of fungicides. Unfortunately, populations of <i>P. infestans</i> resistant to fungicides have been documented. Furthermore, studies have reported that sensitive isolates to the phenylamide fungicide, mefenoxam, become less sensitive in vitro after a single passage through sublethal concentrations of fungicide-amended medium. The first objective of this study was to investigate if isolates of <i>P. infestans</i> are capable of acquiring resistance to two additional systemic fungicides, fluopicolide (benzamide) and cymoxanil (cyanoacetamide-oxime). In contrast to the situation with mefenoxam, exposure of isolates to sublethal concentrations of fluopicolide and cymoxanil did not induce reduced sensitivity to these two fungicides. The second objective was to assess if reduced sensitivity to mefenoxam could occur in naturally sensitive isolates of other <i>Phytophthora</i> species and of <i>Phytopythium</i> sp<i>.</i>, another oomycete plant pathogen. All <i>Phytophthora</i> spp. assessed (<i>P. infestans</i>, <i>P. betacei</i>, and <i>P. pseudocryptogea</i>) as well as <i>Phytopythium</i> sp. acquired resistance to mefenoxam after previous exposure through medium containing 1 µg ml<sup>-1</sup> of mefenoxam. Interestingly, isolate 66 of <i>Phytopythium</i> sp. and the isolate of <i>P. pseudocryptogea</i> tested do not seem to be acquiring resistance to mefenoxam after exposure to medium containing 5 µg ml<sup>-1</sup> of this fungicide. The tested isolates of <i>P. palmivora</i> and <i>P. cinnamomi</i> were extremely sensitive to mefenoxam, and thus it was not possible to perform a second transfer to access acquisition of resistance to this fungicide.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">31765279</PMID><DateCompleted><Year>2020</Year><Month>01</Month><Day>28</Day></DateCompleted><DateRevised><Year>2020</Year><Month>01</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0191-2917</ISSN><JournalIssue CitedMedium="Print"><Volume>104</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Plant disease</Title><ISOAbbreviation>Plant Dis</ISOAbbreviation></Journal><ArticleTitle>Is the Phenomenon of Mefenoxam-Acquired Resistance in <i>Phytophthora infestans</i> Universal?</ArticleTitle><Pagination><MedlinePgn>211-221</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/PDIS-10-18-1906-RE</ELocationID><Abstract><AbstractText><i>Phytophthora infestans</i> is the causal agent of late blight disease of potatoes and tomatoes. This disease causes devastating economic losses each year, and control is mainly achieved by the use of fungicides. Unfortunately, populations of <i>P. infestans</i> resistant to fungicides have been documented. Furthermore, studies have reported that sensitive isolates to the phenylamide fungicide, mefenoxam, become less sensitive in vitro after a single passage through sublethal concentrations of fungicide-amended medium. The first objective of this study was to investigate if isolates of <i>P. infestans</i> are capable of acquiring resistance to two additional systemic fungicides, fluopicolide (benzamide) and cymoxanil (cyanoacetamide-oxime). In contrast to the situation with mefenoxam, exposure of isolates to sublethal concentrations of fluopicolide and cymoxanil did not induce reduced sensitivity to these two fungicides. The second objective was to assess if reduced sensitivity to mefenoxam could occur in naturally sensitive isolates of other <i>Phytophthora</i> species and of <i>Phytopythium</i> sp<i>.</i>, another oomycete plant pathogen. All <i>Phytophthora</i> spp. assessed (<i>P. infestans</i>, <i>P. betacei</i>, and <i>P. pseudocryptogea</i>) as well as <i>Phytopythium</i> sp. acquired resistance to mefenoxam after previous exposure through medium containing 1 µg ml<sup>-1</sup> of mefenoxam. Interestingly, isolate 66 of <i>Phytopythium</i> sp. and the isolate of <i>P. pseudocryptogea</i> tested do not seem to be acquiring resistance to mefenoxam after exposure to medium containing 5 µg ml<sup>-1</sup> of this fungicide. The tested isolates of <i>P. palmivora</i> and <i>P. cinnamomi</i> were extremely sensitive to mefenoxam, and thus it was not possible to perform a second transfer to access acquisition of resistance to this fungicide.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>González-Tobón</LastName><ForeName>Juliana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Childers</LastName><ForeName>Richard</ForeName><Initials>R</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-7137-3192</Identifier><AffiliationInfo><Affiliation>Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, U.S.A.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olave</LastName><ForeName>Carolina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Regnier</LastName><ForeName>Melissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Jaramillo</LastName><ForeName>Alejandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fry</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>School of Integrative Plant Science, Plant Pathology and Plant-Microbe Biology Section, Cornell University, Ithaca, NY, U.S.A.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Restrepo</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9016-1040</Identifier><AffiliationInfo><Affiliation>Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Danies</LastName><ForeName>Giovanna</ForeName><Initials>G</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9689-1140</Identifier><AffiliationInfo><Affiliation>Department of Design, Universidad de los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>11</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Plant Dis</MedlineTA><NlmUniqueID>9882809</NlmUniqueID><ISSNLinking>0191-2917</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005659">Fungicides, Industrial</NameOfSubstance></Chemical><Chemical><RegistryNumber>F1Q54ONN4H</RegistryNumber><NameOfSubstance UI="C473256">mefenoxam</NameOfSubstance></Chemical><Chemical><RegistryNumber>OF5P57N2ZX</RegistryNumber><NameOfSubstance UI="D000409">Alanine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000409" MajorTopicYN="N">Alanine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025141" MajorTopicYN="Y">Drug Resistance, Fungal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005659" MajorTopicYN="N">Fungicides, Industrial</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055750" MajorTopicYN="Y">Phytophthora infestans</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011198" MajorTopicYN="N">Solanum tuberosum</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">P. pseudocryptogea</Keyword><Keyword MajorTopicYN="N">Phytophthora betacei</Keyword><Keyword MajorTopicYN="N">Phytophthora infestans</Keyword><Keyword MajorTopicYN="N">Phytopythium sp.</Keyword><Keyword MajorTopicYN="N">cymoxanil</Keyword><Keyword MajorTopicYN="N">fluopicolide</Keyword><Keyword MajorTopicYN="N">mefenoxam</Keyword><Keyword MajorTopicYN="N">mefenoxam-acquired resistance</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>11</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>11</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31765279</ArticleId><ArticleId IdType="doi">10.1094/PDIS-10-18-1906-RE</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Colombie</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>État de New York</li></region><settlement><li>Cambridge (Massachusetts)</li><li>Ithaca (New York)</li></settlement><orgName><li>Université Cornell</li><li>Université Harvard</li></orgName></list><tree><country name="Colombie"><noRegion><name sortKey="Gonzalez Tob N, Juliana" sort="Gonzalez Tob N, Juliana" uniqKey="Gonzalez Tob N J" first="Juliana" last="González-Tob N">Juliana González-Tob N</name></noRegion><name sortKey="Danies, Giovanna" sort="Danies, Giovanna" uniqKey="Danies G" first="Giovanna" last="Danies">Giovanna Danies</name><name sortKey="Olave, Carolina" sort="Olave, Carolina" uniqKey="Olave C" first="Carolina" last="Olave">Carolina Olave</name><name sortKey="Regnier, Melissa" sort="Regnier, Melissa" uniqKey="Regnier M" first="Melissa" last="Regnier">Melissa Regnier</name><name sortKey="Restrepo, Silvia" sort="Restrepo, Silvia" uniqKey="Restrepo S" first="Silvia" last="Restrepo">Silvia Restrepo</name><name sortKey="Rodriguez Jaramillo, Alejandra" sort="Rodriguez Jaramillo, Alejandra" uniqKey="Rodriguez Jaramillo A" first="Alejandra" last="Rodríguez-Jaramillo">Alejandra Rodríguez-Jaramillo</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Childers, Richard" sort="Childers, Richard" uniqKey="Childers R" first="Richard" last="Childers">Richard Childers</name></region><name sortKey="Fry, William" sort="Fry, William" uniqKey="Fry W" first="William" last="Fry">William Fry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31765279" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PhytophthoraV1
| This area was generated with Dilib version V0.6.38. |  |